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The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals

Christoph Handschin, Sharon Blättler, Adrian Roth, Renate Looser, Mikael Oscarson, Michel R Kaufmann, Michael Podvinec, Carmela Gnerre and Urs A Meyer*

Nuclear Receptor 2004, 2:7 doi:10.1186/1478-1336-2-7

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Evolution of pharmacologic specificity in the pregnane X receptor

Sean Ekins, Erica J Reschly, Lee R Hagey, Matthew D Krasowski BMC Evolutionary Biology 2008, 8:103 (2 April 2008)

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Functional evolution of the vitamin D and pregnane X receptors

Erica J Reschly, Afonso Bainy, Jaco Mattos, Lee R Hagey, Nathan Bahary, Sripal R Mada, Junhai Ou, Raman Venkataramanan, Matthew D Krasowski BMC Evolutionary Biology 2007, 7:222 (12 November 2007)

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Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors)

Matthew D Krasowski, Kazuto Yasuda, Lee R Hagey, Erin G Schuetz Nuclear Receptor 2005, 3:2 (30 September 2005)

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