Nuclear Receptor


Open Access Highly Access Research

Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors)

Matthew D Krasowski1*, Kazuto Yasuda2, Lee R Hagey3 and Erin G Schuetz2

Author Affiliations

1 Department of Pathology, Children's Hospital of Pittsburgh, 5834 Main Tower, 200 Lothrop Street, University of Pittsburgh, Pittsburgh, PA, 15213 USA

2 Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, 38105 USA

3 Department of Medicine, University of California, San Diego, CA, 92093, USA

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Nuclear Receptor 2005, 3:2 doi:10.1186/1478-1336-3-2

Published: 30 September 2005

Additional files

Additional File 1:

Genes used for phylogenetic analysis. Excel file containing accession numbers for all files used in the phylogenetic analysis.

Format: XLS Size: 67KB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional File 2:

Sequences used for phylogenetic analysis by PAML. Text file with complete, full-length nucleotide sequences for all genes used in the PAML analysis. The nucleotide numbers corresponding to the DBD and LBD are also indicated.

Format: ADDI Size: 1010KB Download file

Open Data

Additional File 3:

Results of PAML analysis and treefiles. Excel file containing summary data for all PAML analyses. The log-likelihood for each analysis is given along with additional relevant summary parameters. The methods for statistically comparing nested models are described in Materials and Methods. In addition, the phylogenetic treefile for each analysis is also included.

Format: XLS Size: 400KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data