Most Recent Articles: Nuclear Receptorhttps://nuclear-receptor.biomedcentral.comMost Recent Articles: Nuclear ReceptorThe integration of lipid-sensing and anti-inflammatory effects: how the PPARs play a role in metabolic balancehttps://nuclear-receptor.biomedcentral.com/articles/10.1186/1478-1336-5-1The peroxisomal proliferating-activated receptors (PPARs) are lipid-sensing transcription factors that have a role in embryonic development, but are primarily known for modulating energy metabolism, lipid stor...ReviewFri, 25 May 2007 00:00:00 GMThttps://nuclear-receptor.biomedcentral.com/articles/10.1186/1478-1336-5-1Alistair VW Nunn, Jimmy Bell and Philip Barter2007-05-25T00:00:00ZAssociation of common variation in the PPARAgene with incident myocardial infarction in individuals with type 2 diabetes: A Go-DARTS studyhttps://nuclear-receptor.biomedcentral.com/articles/10.1186/1478-1336-3-4Common variants of the PPARA gene have been found to associate with ischaemic heart disease in non diabetic men. The L162V variant was found to be protective while the C2528G variant increased risk. L162V has als...ResearchFri, 25 Nov 2005 00:00:00 GMThttps://nuclear-receptor.biomedcentral.com/articles/10.1186/1478-1336-3-4Alex SF Doney, Bettina Fischer, Simon P Lee, Andrew D Morris, Graham Leese and Colin NA Palmer2005-11-25T00:00:00ZGene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoformshttps://nuclear-receptor.biomedcentral.com/articles/10.1186/1478-1336-3-3Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors and commonly play an important role in the regulation of lipid homeostasis. To identify human PPARs-responsive gen...ResearchMon, 03 Oct 2005 00:00:00 GMThttps://nuclear-receptor.biomedcentral.com/articles/10.1186/1478-1336-3-3Keisuke Tachibana, Yumi Kobayashi, Toshiya Tanaka, Masayuki Tagami, Akira Sugiyama, Tatsuya Katayama, Chihiro Ueda, Daisuke Yamasaki, Kenji Ishimoto, Mikako Sumitomo, Yasutoshi Uchiyama, Takahide Kohro, Juro Sakai, Takao Hamakubo, Tatsuhiko Kodama and Takefumi Doi2005-10-03T00:00:00ZEvolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors)https://nuclear-receptor.biomedcentral.com/articles/10.1186/1478-1336-3-2The nuclear hormone receptor (NR) superfamily complement in humans is composed of 48 genes with diverse roles in metabolic homeostasis, development, and detoxification. In general, NRs are strongly conserved b...ResearchFri, 30 Sep 2005 00:00:00 GMThttps://nuclear-receptor.biomedcentral.com/articles/10.1186/1478-1336-3-2Matthew D Krasowski, Kazuto Yasuda, Lee R Hagey and Erin G Schuetz2005-09-30T00:00:00ZThyroid hormone receptor binding to DNA and T3-dependent transcriptional activation are inhibited by uremic toxinshttps://nuclear-receptor.biomedcentral.com/articles/10.1186/1478-1336-3-1There is a substantial clinical overlap between chronic renal failure (CRF) and hypothyroidism, suggesting the presence of hypothyroidism in uremic patients. Although CRF patients have low T3 and T4 levels with n...ResearchMon, 04 Apr 2005 00:00:00 GMThttps://nuclear-receptor.biomedcentral.com/articles/10.1186/1478-1336-3-1Guilherme M Santos, Carlos J Pantoja, AluĂ­zio Costa e Silva, Maria C Rodrigues, Ralff C Ribeiro, Luiz A Simeoni, Noureddine Lomri and Francisco AR Neves2005-04-04T00:00:00Z