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The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals.

Handschin C, Blättler S, Roth A, Looser R, Oscarson M, Kaufmann MR, Podvinec M, Gnerre C, Meyer UA.

Nucl Recept. 2004 Oct 12;2(1):7.

PMID: 15479477 [PubMed - as supplied by publisher]

CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR).

Handschin C, Podvinec M, Meyer UA.

Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10769-74.

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Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors.

Moore LB, Maglich JM, McKee DD, Wisely B, Willson TM, Kliewer SA, Lambert MH, Moore JT.

Mol Endocrinol. 2002 May;16(5):977-86.

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Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.

Reschly EJ, Krasowski MD.

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Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor.

Handschin C, Podvinec M, Looser R, Amherd R, Meyer UA.

Mol Pharmacol. 2001 Oct;60(4):681-9.

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Induction of phase I, II and III drug metabolism/transport by xenobiotics.

Xu C, Li CY, Kong AN.

Arch Pharm Res. 2005 Mar;28(3):249-68. Review.

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Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans.

Handschin C, Podvinec M, Stöckli J, Hoffmann K, Meyer UA.

Mol Endocrinol. 2001 Sep;15(9):1571-85.

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Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes.

Rushmore TH, Kong AN.

Curr Drug Metab. 2002 Oct;3(5):481-90. Review.

PMID: 12369894 [PubMed - indexed for MEDLINE]

Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).

Krasowski MD, Yasuda K, Hagey LR, Schuetz EG.

Nucl Recept. 2005 Sep 30;3:2.

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10:

The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.

Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ, Chatterjee B.

Mol Endocrinol. 2007 Sep;21(9):2099-111. Epub 2007 Jun 26.

PMID: 17595319 [PubMed - indexed for MEDLINE]

11:

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification.

Maglich JM, Stoltz CM, Goodwin B, Hawkins-Brown D, Moore JT, Kliewer SA.

Mol Pharmacol. 2002 Sep;62(3):638-46.

PMID: 12181440 [PubMed - indexed for MEDLINE]

12:

CAR and PXR: xenosensors of endocrine disrupters?

Kretschmer XC, Baldwin WS.

Chem Biol Interact. 2005 Aug 15;155(3):111-28. Review.

PMID: 16054614 [PubMed - indexed for MEDLINE]

13:

Orphan nuclear receptor binding site in the human inducible nitric oxide synthase promoter mediates responsiveness to steroid and xenobiotic ligands.

Toell A, Kröncke KD, Kleinert H, Carlberg C.

J Cell Biochem. 2002;85(1):72-82.

PMID: 11891851 [PubMed - indexed for MEDLINE]

14:

Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response.

Wei P, Zhang J, Dowhan DH, Han Y, Moore DD.

Pharmacogenomics J. 2002;2(2):117-26.

PMID: 12049174 [PubMed - indexed for MEDLINE]

15:

Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha.

Ferguson SS, Chen Y, LeCluyse EL, Negishi M, Goldstein JA.

Mol Pharmacol. 2005 Sep;68(3):747-57. Epub 2005 Jun 2.

PMID: 15933212 [PubMed - indexed for MEDLINE]

16:

Transcriptional activation of cytochrome P450 CYP2C45 by drugs is mediated by the chicken xenobiotic receptor (CXR) interacting with a phenobarbital response enhancer unit.

Baader M, Gnerre C, Stegeman JJ, Meyer UA.

J Biol Chem. 2002 May 3;277(18):15647-53. Epub 2002 Feb 26.

PMID: 11867618 [PubMed - indexed for MEDLINE]

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Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands.

Moore LB, Parks DJ, Jones SA, Bledsoe RK, Consler TG, Stimmel JB, Goodwin B, Liddle C, Blanchard SG, Willson TM, Collins JL, Kliewer SA.

J Biol Chem. 2000 May 19;275(20):15122-7.

PMID: 10748001 [PubMed - indexed for MEDLINE]

18:

A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression.

Wang H, Faucette S, Sueyoshi T, Moore R, Ferguson S, Negishi M, LeCluyse EL.

J Biol Chem. 2003 Apr 18;278(16):14146-52. Epub 2003 Feb 5.

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The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.

Jones SA, Moore LB, Shenk JL, Wisely GB, Hamilton GA, McKee DD, Tomkinson NC, LeCluyse EL, Lambert MH, Willson TM, Kliewer SA, Moore JT.

Mol Endocrinol. 2000 Jan;14(1):27-39.

PMID: 10628745 [PubMed - indexed for MEDLINE]

20:

Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.

Cerveny L, Svecova L, Anzenbacherova E, Vrzal R, Staud F, Dvorak Z, Ulrichova J, Anzenbacher P, Pavek P.

Drug Metab Dispos. 2007 Jul;35(7):1032-41. Epub 2007 Mar 28.

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